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Botulinum toxin (BTX) is a neurotoxic protein which is got from the bacterium Clostridium botulinum and related species. It prevents the release of the neurotransmitter acetylcholine from axon endings at the neuromuscular junction and thus causes flaccid paralysis. Infection with the bacterium causes the disease botulism. Study Helps Explain Why Botulinum Toxin Is So Deadly. … By blocking this signaling molecule, tiny amounts of botulinum toxin can cause paralysis and even death through respiratory failure. The bacteria that makes this toxin grows in soil, and can be found inside cans of food that were improperly processed. Botulinum neurotoxin poses a major bioweapon threat because of its extreme potency and lethality; its ease of production, transport, and misuse; and the need for prolonged intensive care among affected persons. A single gram of crystalline toxin, evenly dispersed and inhaled, can kill more than one million people. allergan botox. botox injections
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Firstly, botox (onabotulinumtoxinA) for injection is a sterile, vacuum-dried purified botulinum toxin type A, is got from fermentation of Hall strain Clostridium botulinum type A, and intended for intramuscular, intradetrusor and intradermal use. It is purified from the culture solution by dialysis and a series of acid precipitations to a complex consisting of the neurotoxin, and several accessory proteins.a llergan botox. botox injections
Furthermore, the primary release procedure for this product uses a cell-based potency assay. This is to determine the potency relative to a reference standard. The assay is specific to Allergan’s products. One Unit corresponds to the calculated median intraperitoneal lethal dose (LD50) in mice. Due to specific details of this assay such as the vehicle, dilution scheme, and laboratory protocols, Units of biological activity of this product cannot be compared to nor converted into Units of any other botulinum toxin or any toxin assessed with any other specific assay method. The specific activity of allergan sprecie is approximately 20 Units/nanogram of neurotoxin protein complex. order botox online, botox injections
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In addition, each vial of BOTOX contains either 50 Units of Clostridium botulinum type A neurotoxin complex, 0.25 mg of Albumin Human, and 0.45 mg of sodium chloride; 100 Units of Clostridium botulinum type A neurotoxin complex, 0.5 mg of Albumin Human, and 0.9 mg of sodium chloride; or 200 Units of Clostridium botulinum type A neurotoxin complex. Therefore 1 mg of Albumin Human, and 1.8 mg of sodium chloride in a sterile, vacuum-dried form without a preservative. botox for sale
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Instructions For Safe Use
The potency Units of This product (onabotulinumtoxinA) for injection are specific to the preparation and assay method utilized. They are not interchangeable with other preparations of botulinum toxin products and, therefore, units of biological activity of this injection cannot be compared to nor converted into units of any other botulinum toxin products assessed with any other specific assay method [see WARNINGS AND PRECAUTIONS and DESCRIPTION] .allergan botox
Also, in treating adult patients for one or more indications, the maximum cumulative dose should not exceed 400 Units. In a 3 month interval. botox for sale
The safe and effective use depends upon proper storage of the product, selection of the correct dose. And proper reconstitution and administration techniques. Upper or lower limb spasticity, and may be useful for the treatment of cervical dystonia. Physicians administering must understand the relevant neuromuscular and structural anatomy of the area involved and any alterations to the anatomy due to prior surgical procedures and disease, especially when injecting near the lungs. order botox online
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